Today, many clinicians believe CRRT is the therapy of choice for treatment of Acute Kidney Injury (AKI) patients in the ICU. This is largely driven by the fact that:
- Timely initiation of CRRT has also been shown to provide clinical outcome benefits for critically ill patients1
- Greater intensity2 (dose) also seems to play a contributing role in outcome
- Available evidence from large clinical studies suggests Continuous Renal Replacement Therapy (CRRT) results in a higher rate of renal recovery versus conventional hemodialysis after AKI3
- The right modality choice and a convective component in the prescription also might contribute to better outcome results2
1. Gettings et al: Outcome in post-traumatic acute renal failure when continuous renal replacement therapy is applied early vs. late. Intensive Care Medicine 1999; 25: 805-813
2. Ronco et al: Effects of different doses in continuous veno-venous hemofiltration on outcomes in acute renal failure: a prospective, randomized trial. Lancet 2000; 355: 26-30
3. Bell et al: Continuous renal replacement therapy is associated with less chronic renal failure than intermittent haemodialysis after acute renal failure. Intensive Care Med 2007; 33: 773-780